I have been using the Environ retinols, together with AVST since 2012. I would use Retinol 2 generally and then step-up to Retinol 3 over the winter. This is my second bottle of the new tri-retinoid that replaced Retinol 2 - so far so good - and over winter I will try the forte that replaced Retinol 3. I also regularly use a derma roller.